It is not possible for medication to permanently cure the people suffering from depression. Medications can only relieve the symptoms and make the person feel better so that he can enjoy the rest of his life peacefully and happily. Medications in the form of anti-depressant can be used for curing severe depression where the chemical present in medication changes the chemical activity in the brain. Medications can only be used as a short term relief measure because long term intake can give rise to severe side effects. Medications can also be used along with other therapy under the prescription of doctor. You can also move on to use natural cure for treating severe depression where you can opt for herbal remedies and can also carry out regular exercise. Severe depression can also be cured using cognitive behavior therapy which will help you to change the way in which you react towards any situation in your life which is the cause for making you feel depressed. This therapy cannot be used for providing long lasting depression cure; it can only help you to cope up with stress and problems. Friends and family members can also help the patients to cure severe depression.