Monoamine Oxidase Inhibitors (MAOIs) are the longest standing anti-depressive drug. They were in fact the first ever used antidepressants. Monoamine oxidase inhibitors are antidepressant drugs prescribed for those patients who are or have become resistant to tricyclic antidepressant drugs and/or therapy. However, recently, some new MAOIs, like moclobermide and selegiline, are often a first choice in depression treatments, as they are safer alternatives.

Present-day researchers believe that monoamine oxidase inhibitors works by keeping the monoamine oxidase, a bodily enzyme that breaks down serotonin and norepinephrine, from metabolizing neurotransmitters;

1. 1. Dopamine

Neurotransmitters that influence movement

1. 2. Serotonin

Neurotransmitters that are involved in anxiety, mood, sleep, appetite and sexuality modulations

1. 3. Norepinephrine

Neurotransmitters influencing sleep, attentiveness and stress responsiveness

By reducing the affectivity of monoamine oxidase, the level of these neurotransmitters in the synapse remains high and thus elevates the mood of the patient.

Monoamine Oxidase Inhibitor Drugs include;

• Marplan
• Nardil
• Parnate
• Manerix
• Emsam

Because of the nature of such drugs, it is important to consult a qualified doctor before starting, ending or even switching to antidepressants. The doctor should be informed of any and all medical history as well as lifestyle details, drinking habits etc., so that proper diagnosis can be made and effective treatment can be prescribed.