Monoamine Oxidase Inhibitors (MAOIs) are the oldest antidepressant drug. Monoamine oxidase inhibitors are antidepressant drugs prescribed for those patients who are or have become resistant to tricyclic antidepressant drugs and/or therapy. However, recently, some new MAOIs, like moclobermide and selegiline, are often a first choice in depression treatments, as they are safer alternatives.

Present-day researchers believe that monoamine oxidase inhibitors works by keeping the monoamine oxidase, a bodily enzyme that breaks down serotonin and norepinephrine, from metabolizing neurotransmitters Dopamine, Serotonin, Norepinephrine. By reducing the effectiveness of monoamine oxidase, the level of these neurotransmitters in the synapse remains high. This elevates the mood of the patient.

Monoamine Oxidase Inhibitor Drugs include;

• Marplan
• Nardil
• Parnate
• Manerix
• Emsam

Of these, the ones that have been approved by the Food and Drug Administration are;

• Isocarboxazid (Marplan)
• Phenelzine (Nardil)
• Tranylcypromine (Parnate)
• Moclobemide (Manerix)
• Selegiline (Emsam)

Due to the nature of these drugs, it is imperative to consult a qualified doctor before starting, ending or even switching to antidepressants. The doctor should be up to date of all medical history as well as lifestyle details, drinking habits etc., so that accurate diagnosis can be made and effectual treatment can be arranged.