Combined reuptake inhibitors and receptor blockers are known as dual action anti depressants. Depression is directly related to the mood, which in turn is related to brain chemistry. The brain produces two chemicals called serotonin and norepinephrine. They are neurotransmitters, chemicals responsible for sending signals from brain cell to brain cell. These two particular neurotransmitters have been linked to depression.

The mood improves the longer the neurotransmitters stay in the brain. Combined reuptake inhibitors and receptor blockers make sure to keep neurotransmitters in the brain for as long as possible. The reuptake inhibitors slow down re-absorption and the receptor blockers prevent the neurotransmitters from bonding with the receptors.

There are safety concerns involved in using combined reuptake inhibitors and receptor blockers. Several men have experienced priapism – a persistent erection that is not related to sexual arousal. This can be quite painful and if it occurs the patient should see a doctor right away. Dual action anti depressants have also been associated with liver failure, so those who have liver problems must not take them. And finally, dual action antidepressants have been known to cause seizures, so those with a history of seizing should give dual action antidepressants a pass.