Tricyclic Antidepressants (TCAs) are the oldest form of antidepressant medicine still used today. TCAs slow the rate of re-absorption by nerve cells of norepinephrine and serotonin, the two chemicals that monitor mood, thus raising the level of these chemicals in the brain. This causes the mood-lightening effect of newly released serotonin and norepinephrine.

The effects of Tricyclic Antidepressants are different in different people as a result of the individual’s genetic make-up. It varies depending on how fast a person’s body generally reuptakes serotonins and norepinephrine or a person’s alleles.

In general, Tricyclic Antidepressants are the most commonly prescribed medication form for patients with depression. So, most people who are given the medication can use it effectively.

However, certain people should avoid Tricyclic Antidepressant medications for health purposes. Such people include;

• Drug Allergic

People who are allergic to carbamazepine or any other such psychiatric medication

• Pregnant or Nursing

Women should avoid TCAs while pregnant or nursing at the risk of contaminating breast milk

• Heart Disease Patients

TCA medication is associated with heart attack risks

• Diabetic

Patient’s blood sugar levels may be affected more with the use of TCAs

• Heavily Drug Dependant

TCAs may not be compatible with a number of other medications

As with all medication, Tricyclic Antidepressants should not be used without a doctor’s examination and prescription.